Welcome to Moffitt Cancer Center
 
Department of Cancer Imaging and Metabolism

The Department of Cancer Imaging and Metabolism was initiated in April 2008 with the hiring of Drs. Robert A. Gatenby and Robert J. Gillies as chair and vice-chair of Radiology. 

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Research Projects

Imaging the microenvironment:

Imaging the microenvironment is coordinated by Arig Ibrahim-Hashim, MD. It meets Thursdays from 4-6 pm in Atrium 4 of the SRB. Members of this program include Drs. Ariosto Silva, Yoonseok Kam, and Veronica Estrella. Because of its relevance to therapy, two members of the biomarkers theme, Drs. Wojtkowiak and Cornell, also attend. It is funded by two NIH grants: an R01 (Causes and Consequences of Acid pH) and a U54 (The Physical Microenvironment) as well as grants from Reliable Cancer Therapeutics to support clinical trials (pending).

The goal on this theme is to understand the roles that the physical microenvironment (pH, hypoxia) have on tumor progression and therapy, with explicit considerations of tumor heterogeneity. This work makes extensive use of mathematical modeling. Thus, there is a strong interaction with the Integrated Mathematical Oncology program, IMO. Although this was initiated as a pre-clinical program, since coming to Moffitt, it has been expanded it into clinical trials on the effect of buffers (bicarbonate) on bone pain and progression in non-resectable pancreatic cancers. These trials are in collaboration with Drs. Rachid Baz and Sloan Karver (pain) and Greg Springett and Mo Malafa (pancreatic). Additional trials are planned to test, with “adaptive therapy” models predicting the emergence of resistant phenotypes.
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Latest Group News  View Alll

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3/5/2014: Jasmine Oliver was selected to participate in the 64th Lindau Nobel Laureate Meeting dedicated to Physiology or Medicine, in Lindau Germany from June 29th - July 4th this summer.



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11/2012: The Radiomics Workshop report 2012 is available[View]



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Abstract accepted for WMIC 2012: Characterization of Multivalent Targeted Molecular Imaging Probes



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Allison Cohen's abstract accepted for WMIC 2012: Discovery of Cell-Surface Markers for Molecular Imaging of Lung Cancer