Welcome to Moffitt Cancer Center
Department of Cancer Imaging and Metabolism

The Department of Cancer Imaging and Metabolism was initiated in April 2008 with the hiring of Drs. Robert A. Gatenby and Robert J. Gillies as chair and vice-chair of Radiology. 


Research Projects

Gillies/Gatenby References for buffer therapy:

Gatenby RA, Gillies RJ. Integrated imaging of cancer metabolism. Acad Radiol. 2011 Aug;18(8):929-31. PubMed PMID: 21718952.

Gatenby RA, Gillies RJ, Brown JS. Of cancer and cave fish. Nat Rev Cancer. 2011 Apr;11(4):237-8. PubMed PMID: 21548400.

Perfahl H, Byrne HM, Chen T, Estrella V, Alarcón T, Lapin A, Gatenby RA,Gillies RJ, Lloyd MC, Maini PK, Reuss M, Owen MR. Multiscale modelling of vascular tumour growth in 3D: the roles of domain size and boundary conditions. PLoS One. 2011 Apr 13;6(4):e14790. PubMed PMID: 21533234; PubMed Central PMCID: PMC3076378.

Martin NK, Gaffney EA, Gatenby RA, Gillies RJ, Robey IF, Maini PK. A mathematical model of tumour and blood pHe regulation: The HCO3-/CO2 buffering system. Math Biosci. 2011 Mar;230(1):1-11. Epub 2010 Dec 15. PubMed PMID: 21167185; PubMed Central PMCID: PMC3045481.

Gatenby RA, Gillies RJ, Brown JS. Evolutionary dynamics of cancer prevention. Nat Rev Cancer. 2010 Aug;10(8):526-7. PubMed PMID: 21137109.

Gillies RJ, Anderson AR, Gatenby RA, Morse DL. The biology underlying molecular imaging in oncology: from genome to anatome and back again. Clin  Radiol. 2010 Jul;65(7):517-21. PubMed PMID: 20541651.

Silva AS, Gatenby RA, Gillies RJ, Yunes JA. A quantitative theoretical model for the development of malignancy in ductal carcinoma in situ. J Theor Biol. 2010 Feb 21;262(4):601-13. Epub 2009 Oct 31. PubMed PMID: 19887072.

Gatenby RA, Silva AS, Gillies RJ, Frieden BR. Adaptive therapy. Cancer Res. 2009 Jun 1;69(11):4894-903. PubMed PMID: 19487300.

Robey IF, Baggett BK, Kirkpatrick ND, Roe DJ, Dosescu J, Sloane BF, Hashim AI, Morse DL, Raghunand N, Gatenby RA, Gillies RJ. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res. 2009 Mar 15;69(6):2260-8. Epub 2009 Mar 10. PubMed PMID: 19276390; PubMed Central PMCID: PMC2834485.

Silva AS, Yunes JA, Gillies RJ, Gatenby RA. The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res. 2009 Mar 15;69(6):2677-84. Epub 2009 Mar 10. PubMed PMID: 19276380.

Robey IF, Stephen RM, Brown KS, Baggett BK, Gatenby RA, Gillies RJ. Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia. 2008 Aug;10(8):745-56. PubMed PMID: 18670636; PubMed Central PMCID: PMC2481565.

Gillies RJ, Robey I, Gatenby RA. Causes and consequences of increased glucose metabolism of cancers. J Nucl Med. 2008 Jun;49 Suppl 2:24S-42S. Review. PubMed PMID: 18523064.

Fang JS, Gillies RD, Gatenby RA. Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Semin Cancer Biol. 2008 Oct;18(5):330-7. Epub 2008 Mar 26. Review. PubMed PMID: 18455429; PubMed Central PMCID: PMC2953714.

Moellering RE, Black KC, Krishnamurty C, Baggett BK, Stafford P, Rain M, Gatenby RA, Gillies RJ. Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastasis. 2008;25(4):411-25. Epub 2008 Feb 27. PubMed PMID: 18301995.

Gatenby RA, Gillies RJ. A microenvironmental model of carcinogenesis. Nat Rev Cancer. 2008 Jan;8(1):56-61. Review. PubMed PMID: 18059462.

Gatenby RA, Smallbone K, Maini PK, Rose F, Averill J, Nagle RB, Worrall L, Gillies RJ. Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer. Br J Cancer. 2007 Sep 3;97(5):646-53. Epub 2007 Aug 7. PubMed PMID: 17687336; PubMed Central PMCID: PMC2360372.

Gillies RJ, Gatenby RA. Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis? J Bioenerg Biomembr. 2007 Jun;39(3):251-7. Review.   PubMed PMID: 17624581.

Gatenby RA, Gillies RJ. Glycolysis in cancer: a potential target for therapy. Int J Biochem Cell Biol. 2007;39(7-8):1358-66. Epub 2007 Apr 4. Review. PubMed PMID: 17499003.

Gillies RJ, Gatenby RA. Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev. 2007 Jun;26(2):311-7. Review. PubMed PMID: 17404691.

Smallbone K, Gatenby RA, Gillies RJ, Maini PK, Gavaghan DJ. Metabolic changes during carcinogenesis: potential impact on invasiveness. J Theor Biol. 2007 Feb 21;244(4):703-13. Epub 2006 Sep 16. PubMed PMID: 17055536.

 Gatenby RA, Gawlinski ET, Gmitro AF, Kaylor B, Gillies RJ. Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res. 2006 May 15;66(10):5216-23. PubMed PMID: 16707446.

Gillies RJ, Raghunand N, Garcia-Martin ML, Gatenby RA. pH imaging. A review of pH measurement methods and applications in cancers. IEEE Eng Med Biol Mag. 2004 Sep-Oct;23(5):57-64. Review. PubMed PMID: 15565800.

Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev  Cancer. 2004 Nov;4(11):891-9. Review. PubMed PMID: 15516961.

Raghunand N, Gatenby RA, Gillies RJ. Microenvironmental and cellular consequences of altered blood flow in tumours. Br J Radiol. 2003;76 Spec No 1:S11-22. Review. PubMed PMID: 15456710.



Latest Group News  View Alll


3/5/2014: Jasmine Oliver was selected to participate in the 64th Lindau Nobel Laureate Meeting dedicated to Physiology or Medicine, in Lindau Germany from June 29th - July 4th this summer.


11/2012: The Radiomics Workshop report 2012 is available[View]


Abstract accepted for WMIC 2012: Characterization of Multivalent Targeted Molecular Imaging Probes


Allison Cohen's abstract accepted for WMIC 2012: Discovery of Cell-Surface Markers for Molecular Imaging of Lung Cancer