Welcome to Moffitt Cancer Center
 
Department of Cancer Imaging and Metabolism

The Department of Cancer Imaging and Metabolism was initiated in April 2008 with the hiring of Drs. Robert A. Gatenby and Robert J. Gillies as chair and vice-chair of Radiology. 

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Research Projects

Imaging biomarkers:

Imaging biomarkers is coordinated by Dr. Gary Martinez, PhD.  It meets Wednesdays 2-4 pm in PI-2.  Members of this program include Drs. John Heine, Virendra Kumar, Yuhua Gu, Jon Wojtkowiak, Heather Cornell, Xiaomeng Zhang and Ihor Luhach.  It is funded by three NIH grants: a pre-clinical R01 (Imaging Biomarkers), a clinical U01 (Radiomics), a clinical R01 (Heine mammography) and an ARRA supplement to an N01 (Drs. Dan Sullivan, Hatem Soliman) to add an imaging arm to a proposed trial. 

The focus of this theme is to develop and apply imaging biomarkers to improve cancer therapy and prognosis.  Biomarkers are quantitative measures of tumor physiology or pathology that can monitor or predict response, or predict the presence or recurrence of disease.   read more

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Imaging the microenvironment:

Imaging the microenvironment is coordinated by Arig Ibrahim-Hashim, MD.  It meets Thursdays from 4-6 pm in Atrium 4 of the SRB.  Members of this program include Drs. Sophie Vibet, Ariosto Silva, Yoonseok Kam, and Veronica Estrella.  Because of its relevance to therapy, two members of the biomarkers theme, Drs. Wojtkowiak and Cornell, also attend.  It is funded by two NIH grants: an R01 (Causes and Consequences of Acid pH) and a U54 (The Physical Microenvironment) as well as grants from Reliable Cancer Therapeutics to support clinical trials (pending). read more

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Targeting agents and nanomedicine:

Targeting agents and nanomedicine is coordinated by Dave Morse, PhD.  It meets on Tuesdays from 4-6 pm in PI-2, as well as by telecon with University of Arizona on Mondays from 4-6.  Members include Liping Xu, Amanda Shanks Huynh, Natalie Barkey, Prasanta Dutta, Narges Tafreshi and Kamini Sewda.  It is funded by two NIH grants: an R01 in Pancreatic Cancer and an R01 in melanoma; a UF-Moffitt consortium grant in breast cancer with PERC, and a Bankhead-Coley melanoma pre-SPORE grant in collaboration with Intezyne.  read more

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Buffer Therapy:

Cancer cells metabolize sugars at a remarkably high rate. Normally, metabolized sugars combine with oxygen to produce carbon dioxide, which is removed by the lungs. In cancer, however, the rate of sugar (glucose) consumption is much higher than the availability of oxygen, so the excess metabolized glucose is shunted out of the cells as lactic acid. This excess acid must diffuse to the blood in order to be removed. Because the blood supply in tumors is disorganized, a lot of this acid doesn’t make it into the blood right away and diffuses into the surrounding tissue. Thus, tumors are not only acidic, they also export acid into surrounding tissues. read more


Latest Group News  View Alll

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3/5/2014: Jasmine Oliver was selected to participate in the 64th Lindau Nobel Laureate Meeting dedicated to Physiology or Medicine, in Lindau Germany from June 29th - July 4th this summer.



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11/2012: The Radiomics Workshop report 2012 is available[View]



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Abstract accepted for WMIC 2012: Characterization of Multivalent Targeted Molecular Imaging Probes



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Allison Cohen's abstract accepted for WMIC 2012: Discovery of Cell-Surface Markers for Molecular Imaging of Lung Cancer